Recent Patents on Engineering, Vol 10, No 2 (2016)

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Perspectives on the Application of Supercritical Antisolvent Fractionation Process for the Purification of Plant Extracts: Effects of Operating Parameters and Patent Survey

Mr. R. Abel C. Torres, Ms. Ádina L. Santana, Dr. Diego Tresinari Santos, Dr. M. Angela A. Meireles


A recently developed process entitled Supercritical Antisolvent Fractionation (SAF) was recently described for the fractionation of plant extract solutions using supercritical fluids to give two or more fractions containing bioactive compounds with widely differing polarities. An updated overview of SAF of natural products is presented in this article. In this chapter the perspectives of the use supercritical CO2 (SC-CO2) applied to the fractionation of plant extracts compounds, such as phenolic compounds, lipids, carotenoids, among other components, extracted from seeds, leaves, stems, roots and other parts of the plants are described. The main features and mechanisms of antisolvent techniques that contribute to the understanding of the fundamentals of the supercritical antisolvent fractionation (SAF) process are also described. In addition, the influence of various operating parameters, such as, CO2 temperature and pressure, CO2 flow rate, among others, during SAF process on the purification efficiency and particle morphology and the main differences about the patented SAF processes are discussed.


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