Mini-Reviews in Medicinal Chemistry, Vol 18, No 3 (2018)

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Bone degeneration, Inflammation and Secondary complications of Arthritis: Potential Targets and their Natural inhibitors

Dr. Kesthuru Subbaiah Girish, Dr. Mahadevappa Hemshekhar, Dr. Ram M Thushara, Mr. Mahalingam S Sundaram, Mr. Somanatahpura S NaveenKumar, Mr. Manoj Paul, Prof. Kempaiah Kemparaju

Abstract


Though cartilage degradation does the major damage during arthritis, the subsequent bone loss cannot be neglected. Progress in arthritis research has identified the clinical importance of bone erosion in destructive arthritis. Studies have showed the key role played by osteoclasts and receptor activator of nuclear factor kappaB ligand (RANKL) signaling in bone erosion. Cathepsins and tartrate resistant acid phosphatase (TRAP) are considered key enzymatic factors contributing to bone erosion. Further, reactive oxygen species (ROS) formed at the ruffled border of osteoclasts also causes bone resorption and matrix degradation. Besides, severe inflammation during arthritis induces bone erosion by aiding in Ca2+ removal and activating osteoclastogenesis. The inflammatory cytokines and ROS influence osteoclast differentiation by regulating osteoclast-lineage cells or by acting on other cells to regulate the expression of RANKL and osteoprotegerin (OPG). The enhanced production of pro-inflammatory cytokines and ROS in arthritis will stimulate tissue injury by means of oxidative damage leading to vital organ damage and synovial and circulatory cell apoptosis. Thus, blocking enzymatic and non-enzymatic factors responsible for bone erosion and inflammation is considered a prime strategy in the management of arthritis. In this review we provide an overview of the mechanisms of bone erosion, inflammation and associated oxidative stress/damage during arthritis perpetuation along with shedding light on potential targets. The article also describes the possible natural therapeutic agents that could prevent bone loss and inflammation, and related secondary complications of arthritis.

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