Mini-Reviews in Medicinal Chemistry, Vol 17, No 17 (2017)

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Characterization of a novel polysaccharide-iron(III) complex and its anti-anemia and nonspecific immune regulating activities

Ms. Yun ZHANG, Dr. Fanyi MA, Dr. Jinhua ZHU, Prof. Zuliang DU, Prof. Yingyong ZHAO, Prof. Xiuhua LIU


Dioscorea opposita Thunb. is the famous food and traditional medicine in China and it was rich in polysaccharides. Polysaccharides of D. Opposita Thunb. possess immunoregulatory activity, free radical scavenging activity and anti-diabetic activity. A novel polysaccharide-iron(III) complex (CYPIC) was synthesized by using crude polysaccharide extracted from Dioscorea opposita Thunb. The component, structure, morphology and molecular weights of CYPIC were analysed, and the anti-anemia, acute toxicity and nonspecific immune regulating activities of CYPIC were assayed. The results showed that CYPIC could not only improve the immunity but also cure iron deficiency anemia. Therefore, CYPIC has the potential to be used as an iron supplement for the treatment of iron deficiency anemia. The large scale industrial production was suggested due to the simple preparation processing of CYPIC.


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