Mini-Reviews in Medicinal Chemistry, Vol 18, No 18 (2018)

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1,2,4-Oxadiazole as a privileged scaffold for anti-inflammatory and analgesic activities: A complete review.

Dr. Gita Chawla, Ms. chanda ranjan, Dr. Anees Ahmad Siddiqui

Abstract


1,2,4-Oxadiazole is one of the important heterocycles used by medicinal chemists in designing a new therapeutic molecule. The compounds containing this nucleus are reported to have a wide range of pharmaceutical and biological applications including anti-inflammatory and analgesic activities. The fused and pendent 1,2,4-oxadiazole moiety has been traced in a number of well established, commercially available drugs. This review article provides an up to date information about techniques adopted for the synthesis of 1,2,4-oxadiazoles, and their therapeutic importance as an anti-inflammatory and analgesic agents.

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