Mini-Reviews in Medicinal Chemistry, Vol 19, No 6 (2019)

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A Review Exploring Therapeutic Worth of 1,3,4-Oxadiazole Tailored Compounds

Ms. Garima Verma, Mr. Mohemmed Faraz Khan, Mr. Wasim Akhtar, Dr. Mohammad Mumtaz Alam, Dr. Mymoona Akhter, Dr. Mohammad Shaquiquzzaman

Abstract


1,3,4-Oxadiazole ring is an important five-membered aromatic heterocycle widely present in a number of synthetic molecules. The unique structural feature of 1,3,4-oxadiazole ring with pyridine type of nitrogen atom is beneficial for 1,3,4-oxadiazole derivatives to readily bind with a variety of enzymes and receptors in biological systems through diverse weak interactions, thereby exhibiting broad bioactivities. The related research and developments of 1,3,4-oxadiazole-based medicinal chemistry have become a rapidly developing and increasingly active topic. Particularly, numerous 1,3,4-oxadiazole based compounds as clinical drugs have been extensively used in the clinic to treat various types of diseases with high therapeutic potency, which have shown the enormous development value. This work systematically gives a comprehensive review in current developments of 1,3,4-oxadiazole based compounds in the whole range of medicinal chemistry as anticancer, antifungal, antibacterial, antitubercular, anti-inflammatory, antineuropathic, antihypertensive, antihistaminic, antiparasitic, antiobesity, antiviral, and other medicinal agents. It is hoped that this review will be helpful for new thoughts in the quest for rational designs of more active and less toxic 1,3,4-oxadiazole based medicinal drugs.

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